The Fusion scored well in Insurance Institute for Highway Safety crash tests, with ratings of Good (the highest) for front- and side-impact protection. Seat-mounted side-impact airbags for the front seats and side curtain airbags designed to protect front and rear occupants in a side impact are standard. Antilock braking is now standard on all Fusions, as is a tire pressure monitoring system.

The lack of an electronic stability system in the Fusion is a glaring omission, as the feature is being incorporated into other cars across the market, including competing models — and more affordable ones to boot.